AMP-activated protein kinase (AMPK) β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise

AMP-activated protein kinase (AMPK) β1 or β2 subunits are required for assembling of AMPK heterotrimers and are important for regulating enzyme activity and cellular localization. In skeletal muscle, α2β2γ3-containing heterotrimers predominate. However, compensatory up-regulation and redundancy of A...

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Hlavní autoři: O'Neill, Hayley M., Maarbjerg, Stine J., Crane, Justin D., Jeppesen, Jacob, Jørgensen, Sebastian B., Schertzer, Jonathan D., Shyroka, Olga, Kiens, Bente, van Denderen, Bryce J., Tarnopolsky, Mark A., Kemp, Bruce E., Richter, Erik A., Steinberg, Gregory R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179037/
https://ncbi.nlm.nih.gov/pubmed/21896769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105062108
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