AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

The AMP-activated protein kinase (AMPK) is an αβγ heterotrimer that regulates appetite and fuel metabolism. We have generated AMPK β1(−/−) mice on a C57Bl/6 background that are viable, fertile, survived greater than 2 years, and display no visible brain developmental defects. These mice have a 90% r...

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Detalhes bibliográficos
Main Authors: Dzamko, Nicolas, van Denderen, Bryce J. W., Hevener, Andrea L., Jørgensen, Sebastian Beck, Honeyman, Jane, Galic, Sandra, Chen, Zhi-Ping, Watt, Matthew J., Campbell, Duncan J., Steinberg, Gregory R., Kemp, Bruce E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Metabolism and Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804155/
https://ncbi.nlm.nih.gov/pubmed/19892703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.056762
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