Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance

OBJECTIVE: Macrophage secretion of proinflammatory cytokines contributes to the pathogenesis of obesity-related insulin resistance. An important regulator of inflammation is the suppressor of cytokine signaling-1 (SOCS1), which inhibits the JAK-STAT and toll-like receptor-4 (TLR4) pathways. Despite...

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Main Authors: Sachithanandan, Nirupa, Graham, Kate L., Galic, Sandra, Honeyman, Jane E., Fynch, Stacey L., Hewitt, Kimberly A., Steinberg, Gregory R., Kay, Thomas W.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2011
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142066/
https://ncbi.nlm.nih.gov/pubmed/21646388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0259
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