Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity

AMP-activated protein kinase (AMPK) β subunits (β1 and β2) provide scaffolds for binding α and γ subunits and contain a carbohydrate-binding module important for regulating enzyme activity. We generated C57Bl/6 mice with germline deletion of AMPK β2 (β2 KO) and examined AMPK expression and activity,...

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Main Authors: Steinberg, Gregory R., O'Neill, Hayley M., Dzamko, Nicolas L., Galic, Sandra, Naim, Tim, Koopman, René, Jørgensen, Sebastian B., Honeyman, Jane, Hewitt, Kimberly, Chen, Zhi-Ping, Schertzer, Jonathan D., Scott, John W., Koentgen, Frank, Lynch, Gordon S., Watt, Matthew J., van Denderen, Bryce J. W., Campbell, Duncan J., Kemp, Bruce E.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988326/
https://ncbi.nlm.nih.gov/pubmed/20855892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.102434
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