AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging

The AMP-activated protein kinase (AMPK) activates autophagy, but its role in aging and fasting-induced muscle function has not been defined. Here we report that fasting mice lacking skeletal muscle AMPK (AMPK-MKO) results in hypoglycemia and hyperketosis. This is not due to defective fatty acid oxid...

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Vydáno v:Cell Metab
Hlavní autoři: Bujak, Adam L., Crane, Justin D., Lally, James S., Ford, Rebecca J., Kang, Sally J., Rebalka, Irena A., Green, Alex E., Kemp, Bruce E., Hawke, Thomas J., Schertzer, Jonathan D., Steinberg, Gregory R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5233441/
https://ncbi.nlm.nih.gov/pubmed/26039451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.05.016
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