Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin–sensitizing effects of metformin

The obesity epidemic has led to an increased incidence of non–alcoholic fatty liver disease (NAFLD) and type 2 diabetes. AMP–activated protein kinase (Ampk) regulates energy homeostasis and is activated by cellular stress, hormones and the widely prescribed anti–type 2 diabetic drug metformin(1,2)....

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Publicado no:Nat Med
Main Authors: Fullerton, Morgan D., Galic, Sandra, Marcinko, Katarina, Sikkema, Sarah, Pulinilkunnil, Thomas, Chen, Zhi–Ping, O’Neill, Hayley M., Ford, Rebecca J., Palanivel, Rengasamy, O’Brien, Matthew, Hardie, D. Grahame, Macaulay, S. Lance, Schertzer, Jonathan D., Dyck, Jason R. B., van Denderen, Bryce J., Kemp, Bruce E., Steinberg, Gregory R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965268/
https://ncbi.nlm.nih.gov/pubmed/24185692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3372
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