Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin–sensitizing effects of metformin

The obesity epidemic has led to an increased incidence of non–alcoholic fatty liver disease (NAFLD) and type 2 diabetes. AMP–activated protein kinase (Ampk) regulates energy homeostasis and is activated by cellular stress, hormones and the widely prescribed anti–type 2 diabetic drug metformin(1,2)....

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Bibliografski detalji
Izdano u:Nat Med
Glavni autori: Fullerton, Morgan D., Galic, Sandra, Marcinko, Katarina, Sikkema, Sarah, Pulinilkunnil, Thomas, Chen, Zhi–Ping, O’Neill, Hayley M., Ford, Rebecca J., Palanivel, Rengasamy, O’Brien, Matthew, Hardie, D. Grahame, Macaulay, S. Lance, Schertzer, Jonathan D., Dyck, Jason R. B., van Denderen, Bryce J., Kemp, Bruce E., Steinberg, Gregory R.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965268/
https://ncbi.nlm.nih.gov/pubmed/24185692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3372
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