Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

Despite widespread use of statins to reduce low-density lipoprotein cholesterol (LDL-C) and associated atherosclerotic cardiovascular risk, many patients do not achieve sufficient LDL-C lowering due to muscle-related side effects, indicating novel treatment strategies are required. Bempedoic acid (E...

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Publicado no:Nat Commun
Main Authors: Pinkosky, Stephen L., Newton, Roger S., Day, Emily A., Ford, Rebecca J., Lhotak, Sarka, Austin, Richard C., Birch, Carolyn M., Smith, Brennan K., Filippov, Sergey, Groot, Pieter H.E., Steinberg, Gregory R., Lalwani, Narendra D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133702/
https://ncbi.nlm.nih.gov/pubmed/27892461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13457
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