LDL-cholesterol reduction in patients with hypercholesterolemia by modulation of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase

PURPOSE OF REVIEW: To review the profile of ETC-1002, as shown in preclinical and clinical studies, including LDL-cholesterol (LDL-C)-lowering activity and beneficial effects on other cardiometabolic risk markers as they relate to the inhibition of adenosine triphosphate-citrate lyase and the activa...

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Detalhes bibliográficos
Main Authors: Filippov, Sergey, Pinkosky, Stephen L., Newton, Roger S.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2014
Assuntos:
HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162331/
https://ncbi.nlm.nih.gov/pubmed/24978142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MOL.0000000000000091
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