The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076.

ATP citrate (pro-S)-lyase (EC 4.1.3.8), a cytosolic enzyme that generates acetyl-CoA for cholesterol and fatty acid synthesis de novo, is a potential target for hypolipidaemic intervention. Here we describe the biological effects of the inhibition of ATP citrate-lyase on lipid metabolism in Hep G2 c...

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Autori principali: Pearce, N J, Yates, J W, Berkhout, T A, Jackson, B, Tew, D, Boyd, H, Camilleri, P, Sweeney, P, Gribble, A D, Shaw, A, Groot, P H
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1998
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1219669/
https://ncbi.nlm.nih.gov/pubmed/9693110
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