Apoptotic agents

Por Fennell, Dean A.
Publicado no Transl Lung Cancer Res (2013)

Unlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer

Por Fennell, Dean A, Swanton, Charles
Publicado em 2012

Circumventing HSP90 inhibitors via apoptosis block

Por Fennell, Dean A., Busacca, Sara
Publicado no Oncoscience (2015)

Bcl-2 Family Proteins Contribute to Apoptotic Resistance in Lung Cancer Multicellular Spheroids

Por Yang, Tsung-Ming, Barbone, Dario, Fennell, Dean A., Broaddus, V. Courtney
Publicado em 2009

Voltage dependent anion channel-1 regulates death receptor mediated apoptosis by enabling cleavage of caspase-8

Por Chacko, Alex D, Liberante, Fabio, Paul, Ian, Longley, Daniel B, Fennell, Dean A
Publicado em 2010

Gene Expression Meta-Analysis Identifies VDAC1 as a Predictor of Poor Outcome in Early Stage Non-Small Cell Lung Cancer

Por Grills, Claire, Jithesh, Puthen V., Blayney, Jaine, Zhang, Shu-Dong, Fennell, Dean A.
Publicado em 2011

Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs

Por Bayliss, Richard, Choi, Jene, Fennell, Dean A., Fry, Andrew M., Richards, Mark W.
Publicado no Cell Mol Life Sci (2016)

Dynamical Systems Analysis of Mitochondrial BAK Activation Kinetics Predicts Resistance to BH3 Domains

Por Grills, Claire, Crawford, Nyree, Chacko, Alex, Johnston, Patrick G., O'Rourke, Francesca, Fennell, Dean A.
Publicado em 2008

Ultra-Fast Processing of Gigapixel Tissue MicroArray Images Using High Performance Computing

Por Wang, Yinhai, McCleary, David, Wang, Ching-Wei, Kelly, Paul, James, Jackie, Fennell, Dean A., Hamilton, Peter
Publicado no Anal Cell Pathol (Amst) (2010)

A TMA De-Arraying Method for High Throughput Biomarker Discovery in Tissue Research

Por Wang, Yinhai, Savage, Kienan, Grills, Claire, McCavigan, Andrena, James, Jacqueline A., Fennell, Dean A., Hamilton, Peter W.
Publicado em 2011

Src and ADAM-17-Mediated Shedding of Transforming Growth Factor-α Is a Mechanism of Acute Resistance to TRAIL

Por Van Schaeybroeck, Sandra, Kelly, Donal M., Kyula, Joan, Stokesberry, Susan, Fennell, Dean A., Johnston, Patrick G., Longley, Daniel B.
Publicado em 2008

The deubiquitinating enzyme USP17 is associated with nonsmall cell lung cancer (NSCLC) recurrence and metastasis

Por McFarlane, Cheryl, McFarlane, Suzanne, Paul, Ian, Arthur, Kenneth, Scheaff, Michael, Kerr, Keith, Stevenson, Michael, Fennell, Dean A., Johnston, James A.
Publicado em 2013

SIRT1 at the crossroads of AKT1 and ERβ in malignant pleural mesothelioma cells

Por Pinton, Giulia, Zonca, Sara, Manente, Arcangela G., Cavaletto, Maria, Borroni, Ester, Daga, Antonio, Jithesh, Puthen V., Fennell, Dean, Nilsson, Stefan, Moro, Laura
Publicado no Oncotarget (2016)

Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain

Por Richards, Mark W., Law, Edward W. P., Rennalls, La’Verne P., Busacca, Sara, O’Regan, Laura, Fry, Andrew M., Fennell, Dean A., Bayliss, Richard
Publicado em 2014

Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma

Por Barbone, Dario, Van Dam, Loes, Follo, Carlo, Jithesh, Puthen V., Zhang, Shu-Dong, Richards, William G., Bueno, Raphael, Fennell, Dean A., Broaddus, V. Courtney
Publicado no PLoS One (2016)

Vorinostat Eliminates Multicellular Resistance of Mesothelioma 3D Spheroids via Restoration of Noxa Expression

Por Barbone, Dario, Cheung, Priscilla, Battula, Sailaja, Busacca, Sara, Gray, Steven G., Longley, Daniel B., Bueno, Raphael, Sugarbaker, David J., Fennell, Dean A., Broaddus, V. Courtney
Publicado em 2012

Association between Gene Expression Profiles and Clinical Outcome of Pemetrexed-Based Treatment in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer: Exploratory Resul...

Por Fennell, Dean A., Myrand, Scott P., Nguyen, Tuan S., Ferry, David, Kerr, Keith M., Maxwell, Perry, Moore, Stephen D., Visseren-Grul, Carla, Das, Mayukh, Nicolson, Marianne C.
Publicado em 2014

BAK and NOXA Are Critical Determinants of Mitochondrial Apoptosis Induced by Bortezomib in Mesothelioma

Por Busacca, Sara, Chacko, Alex D., Klabatsa, Astero, Arthur, Kenneth, Sheaff, Michael, Gunasekharan, Vignesh K., Gorski, Julia J., El-Tanani, Mohamed, Broaddus, V. Courtney, Gaudino, Giovanni, Fennell, Dean A.
Publicado em 2013

Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells

Por Yuen, Hiu-Fung, Abramczyk, Olga, Montgomery, Grant, Chan, Ka-Kui, Huang, Yu-Han, Sasazuki, Takehiko, Shirasawa, Senji, Gopesh, Srivastava, Chan, Kwok-Wah, Fennell, Dean, Janne, Pasi, El-Tanani, Mohamed, Murray, James T.
Publicado em 2012

Generation and Characterisation of Cisplatin-Resistant Non-Small Cell Lung Cancer Cell Lines Displaying a Stem-Like Signature

Por Barr, Martin P., Gray, Steven G., Hoffmann, Andreas C., Hilger, Ralf A., Thomale, Juergen, O’Flaherty, John D., Fennell, Dean A., Richard, Derek, O’Leary, John J., O’Byrne, Kenneth J.
Publicado em 2013