Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain

Proteins of the echinoderm microtubule-associated protein (EMAP)-like (EML) family contribute to formation of the mitotic spindle and interphase microtubule network. They contain a unique hydrophobic EML protein (HELP) motif and a variable number of WD40 repeats. Recurrent gene rearrangements in non...

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Detalhes bibliográficos
Main Authors: Richards, Mark W., Law, Edward W. P., Rennalls, La’Verne P., Busacca, Sara, O’Regan, Laura, Fry, Andrew M., Fennell, Dean A., Bayliss, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986153/
https://ncbi.nlm.nih.gov/pubmed/24706829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322892111
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