EML4–ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7

EML4–ALK is an oncogenic fusion present in ∼5% of non-small cell lung cancers. However, alternative breakpoints in the EML4 gene lead to distinct variants of EML4–ALK with different patient outcomes. Here, we show that, in cell models, EML4–ALK variant 3 (V3), which is linked to accelerated metastat...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: O'Regan, Laura, Barone, Giancarlo, Adib, Rozita, Woo, Chang Gok, Jeong, Hui Jeong, Richardson, Emily L., Richards, Mark W., Muller, Patricia A. J., Collis, Spencer J., Fennell, Dean A., Choi, Jene, Bayliss, Richard, Fry, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7240300/
https://ncbi.nlm.nih.gov/pubmed/32184261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.241505
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