Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization

Mitotic spindle assembly requires the regulated activities of protein kinases such as Nek7 and Nek9. Nek7 is autoinhibited by the protrusion of Tyr97 into the active site and activated by the Nek9 non-catalytic C-terminal domain (CTD). CTD binding apparently releases autoinhibition because mutation...

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Udgivet i:Nat Commun
Main Authors: Haq, Tamanna, Richards, Mark W., Burgess, Selena G., Gallego, Pablo, Yeoh, Sharon, O'Regan, Laura, Reverter, David, Roig, Joan, Fry, Andrew M., Bayliss, Richard
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632185/
https://ncbi.nlm.nih.gov/pubmed/26522158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9771
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