Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma

To investigate the underlying causes of chemoresistance in malignant pleural mesothelioma, we have studied mesothelioma cell lines as 3D spheroids, which acquire increased chemoresistance compared to 2D monolayers. We asked whether the gene expression of 3D spheroids would reveal mechanisms of resis...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Barbone, Dario, Van Dam, Loes, Follo, Carlo, Jithesh, Puthen V., Zhang, Shu-Dong, Richards, William G., Bueno, Raphael, Fennell, Dean A., Broaddus, V. Courtney
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794185/
https://ncbi.nlm.nih.gov/pubmed/26982031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150044
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