Identification of Residues Contributing to A2 Domain-dependent Structural Stability in Factor VIII and Factor VIIIa

著者: Wakabayashi, Hironao, Fay, Philip J.
出版事項 2008

Modification of inter-domain interfaces within the A3C1C2 subunit of factor VIII affects its stability and activity

著者: Wakabayashi, Hironao, Fay, Philip J.
出版事項 2013

Replacing the Factor VIII C1 Domain with a Second C2 Domain Reduces Factor VIII Stability and Affinity for Factor IXa

著者: Wakabayashi, Hironao, Fay, Philip J.
出版事項 2013

Molecular Orientation of Factor VIIIa on the Phospholipid Membrane Surface Determined by Fluorescence Resonance Energy Transfer

著者: Wakabayashi, Hironao, Fay, Philip J.
出版年 Biochem J (2013)

Acidic Residues C-Terminal to the A2 Domain Facilitate Thrombin-Catalyzed Activation of Factor VIII

著者: Newell, Jennifer L., Fay, Philip J.
出版事項 2008

Cleavage at Arg-1689 Influences Heavy Chain Cleavages during Thrombin-catalyzed Activation of Factor VIII

著者: Newell, Jennifer L., Fay, Philip J.
出版事項 2009

Factor VIII Light Chain Contains a Binding Site for Factor X That Contributes to the Catalytic Efficiency of Factor Xase()

著者: Takeyama, Masahiro, Wakabayashi, Hironao, Fay, Philip J.
出版事項 2012

Contribution of Factor VIII Light Chain Residues 2007–2016 to an Activated Protein C-Interactive Site

著者: Takeyama, Masahiro, Wakabayashi, Hironao, Fay, Philip J.
出版事項 2012

Cofactor Activity in Factor VIIIa of the Blood Clotting Pathway Is Stabilized by an Interdomain Bond between His(281) and Ser(524) Formed in Factor VIII

著者: Wakabayashi, Hironao, Monaghan, Morgan, Fay, Philip J.
出版事項 2014

Factor VIII Lacking the C2 Domain Retains Cofactor Activity in Vitro

著者: Wakabayashi, Hironao, Griffiths, Amy E., Fay, Philip J.
出版事項 2010

Combining mutations of charged residues at the A2 domain interface enhances factor VIII stability over single point mutations

著者: Wakabayashi, Hironao, Griffiths, Amy E., Fay, Philip J.
出版事項 2008

Increasing Hydrophobicity or Disulfide Bridging at the Factor VIII A1 and C2 Domain Interface Enhances Procofactor Stability

著者: Wakabayashi, Hironao, Griffiths, Amy E., Fay, Philip J.
出版事項 2011

Factor VIIIa A2 Subunit Shows a High Affinity Interaction with Factor IXa: CONTRIBUTION OF A2 SUBUNIT RESIDUES 707-714 TO THE INTERACTION WITH FACTOR IXa

著者: Griffiths, Amy E., Rydkin, Ivan, Fay, Philip J.
出版事項 2013

Combining mutations that modulate inter-subunit interactions and proteolytic inactivation enhance the stability of factor VIIIa()

著者: Wakabayashi, Hironao, Wintermute, Jennifer M., Fay, Philip J.
出版年 Thromb Haemost (2014)

Thrombin-catalyzed activation of factor VIII with His substituted for Arg372 at the P(1) site

著者: Nogami, Keiji, Zhou, Qian, Wakabayashi, Hironao, Fay, Philip J.
出版事項 2005

Sequences Flanking Arg(336) in Factor VIIIa Modulate Factor Xa-catalyzed Cleavage Rates at this Site and Cofactor Function

著者: DeAngelis, Jennifer P., Wakabayashi, Hironao, Fay, Philip J.
出版事項 2012

Generation of enhanced stability factor VIII variants by replacement of charged residues at the A2 domain interface

著者: Wakabayashi, Hironao, Varfaj, Fatbardha, DeAngelis, Jennifer, Fay, Philip J.
出版事項 2008

Identification of Residues in the 558-Loop of Factor VIIIa A2 Subunit That Interact with Factor IXa

著者: Jagannathan, Indu, Ichikawa, H. Travis, Kruger, Tricia, Fay, Philip J.
出版事項 2009

P3-P3' Residues Flanking Scissile Bonds in Factor VIII Modulate Rates of Substrate Cleavage and Procofactor Activation by Thrombin

著者: Newell-Caito, Jennifer L., Griffiths, Amy E., Fay, Philip J.
出版事項 2012

Template Dimerization Promotes an Acceptor Invasion-Induced Transfer Mechanism during Human Immunodeficiency Virus Type 1 Minus-Strand Synthesis

著者: Balakrishnan, Mini, Roques, Bernard P., Fay, Philip J., Bambara, Robert A.
出版事項 2003