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Thrombin-catalyzed activation of factor VIII with His substituted for Arg372 at the P(1) site
Thrombin-catalyzed proteolysis at Arg372 of factor VIII is essential for procofactor activation. However, hemophilia A patients with the missense mutation Arg372 to His possess a mild to moderate phenotype yet show no detectable cleavage at this bond. To evaluate this discrepancy, we prepared and st...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
© 2005 by The American Society of Hematology
2005
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895030/ https://ncbi.nlm.nih.gov/pubmed/15705787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-10-3939 |
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