Thrombin-catalyzed activation of factor VIII with His substituted for Arg372 at the P(1) site

Thrombin-catalyzed proteolysis at Arg372 of factor VIII is essential for procofactor activation. However, hemophilia A patients with the missense mutation Arg372 to His possess a mild to moderate phenotype yet show no detectable cleavage at this bond. To evaluate this discrepancy, we prepared and st...

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Bibliografiske detaljer
Main Authors: Nogami, Keiji, Zhou, Qian, Wakabayashi, Hironao, Fay, Philip J.
Format: Artigo
Sprog:Inglês
Udgivet: © 2005 by The American Society of Hematology 2005
Fag:
Hemostasis, Thrombosis, and Vascular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895030/
https://ncbi.nlm.nih.gov/pubmed/15705787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-10-3939
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