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Contribution of Factor VIII Light Chain Residues 2007–2016 to an Activated Protein C-Interactive Site
Although factor (F) VIIIa is inactivated by activated protein C (APC) through cleavages in the FVIII heavy chain-derived A1 (Arg(336)) and A2 subunits (Arg(562)), the FVIII light chain (LC) contributes to catalysis by binding the enzyme. ELISA-based binding assays showed that FVIII and FVIII LC boun...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3665284/ https://ncbi.nlm.nih.gov/pubmed/23224054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH12-08-0561 |
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