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Identification of Residues Contributing to A2 Domain-dependent Structural Stability in Factor VIII and Factor VIIIa
Factor VIII circulates as a heterodimer composed of heavy (A1A2B domains) and light (A3C1C2 domains) chains, whereas the contiguous A1A2 domains are separate subunits in the active cofactor, factor VIIIa. Whereas the A1 subunit maintains a stable interaction with the A3C1C2 subunit, the A2 subunit i...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2008
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2431055/ https://ncbi.nlm.nih.gov/pubmed/18299331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710252200 |
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