Identification of Plasmin-interactive Sites in the Light Chain of Factor VIII Responsible for Proteolytic Cleavage at Lys(36)

We have recently reported that plasmin likely associates with the factor VIII light chain to proteolyze at Lys(36) within the A1 domain. In this study, we determined that the rate of plasmin-catalyzed inactivation on the forms of factor VIIIa containing A1-(1–336) and (1722)A3C1C2, reflecting Lys(36...

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Detalhes bibliográficos
Main Authors: Nogami, Keiji, Nishiya, Katsumi, Saenko, Evgueni L., Takeyama, Masahiro, Ogiwara, Kenichi, Yoshioka, Akira, Shima, Midori
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652336/
https://ncbi.nlm.nih.gov/pubmed/19126539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802224200
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