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Identification of Plasmin-interactive Sites in the Light Chain of Factor VIII Responsible for Proteolytic Cleavage at Lys(36)
We have recently reported that plasmin likely associates with the factor VIII light chain to proteolyze at Lys(36) within the A1 domain. In this study, we determined that the rate of plasmin-catalyzed inactivation on the forms of factor VIIIa containing A1-(1–336) and (1722)A3C1C2, reflecting Lys(36...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Biochemistry and Molecular Biology
2009
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2652336/ https://ncbi.nlm.nih.gov/pubmed/19126539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802224200 |
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