Generation of enhanced stability factor VIII variants by replacement of charged residues at the A2 domain interface

Factor VIII consists of a heavy chain (A1A2B domains) and light chain (A3C1C2 domains), whereas the contiguous A1A2 domains are separate subunits in the cofactor, factor VIIIa. The intrinsic instability of the cofactor results from weak affinity interactions of the A2 subunit within factor VIIIa. Th...

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Bibliographic Details
Main Authors: Wakabayashi, Hironao, Varfaj, Fatbardha, DeAngelis, Jennifer, Fay, Philip J.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2008
Subjects:
Hemostasis, Thrombosis, and Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556611/
https://ncbi.nlm.nih.gov/pubmed/18650448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-142158
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