Učitavanje...
Generation of enhanced stability factor VIII variants by replacement of charged residues at the A2 domain interface
Factor VIII consists of a heavy chain (A1A2B domains) and light chain (A3C1C2 domains), whereas the contiguous A1A2 domains are separate subunits in the cofactor, factor VIIIa. The intrinsic instability of the cofactor results from weak affinity interactions of the A2 subunit within factor VIIIa. Th...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society of Hematology
2008
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2556611/ https://ncbi.nlm.nih.gov/pubmed/18650448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-142158 |
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