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Modification of inter-domain interfaces within the A3C1C2 subunit of factor VIII affects its stability and activity
Factor (F)VIII consists of a heavy chain [A1(a1)A2(a2)B domains] and light chain [(a3)A3C1C2 domains]. Several reports have shown significant changes in FVIII stability and/or activity following selected mutations at the interfaces of the A1-A2, A1-A3, A2-A3, or A1-C2 domains. In this study the rema...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3731059/ https://ncbi.nlm.nih.gov/pubmed/23659383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400295x |
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