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P3-P3' Residues Flanking Scissile Bonds in Factor VIII Modulate Rates of Substrate Cleavage and Procofactor Activation by Thrombin

Thrombin-catalyzed activation of factor VIII (FVIII) occurs through proteolysis at three P1 Arg residues: Arg(372) and Arg(740) in the FVIII heavy chain and Arg(1689) in the FVIII light chain. Cleavage at the latter two sites is relatively fast compared with cleavage at Arg(372), which appears rate...

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Autores principales: Newell-Caito, Jennifer L., Griffiths, Amy E., Fay, Philip J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414668/
https://ncbi.nlm.nih.gov/pubmed/22455313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300070z
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