Identification of Residues Contributing to A2 Domain-dependent Structural Stability in Factor VIII and Factor VIIIa

ανά Wakabayashi, Hironao, Fay, Philip J.
Έκδοση 2008

Modification of inter-domain interfaces within the A3C1C2 subunit of factor VIII affects its stability and activity

ανά Wakabayashi, Hironao, Fay, Philip J.
Έκδοση 2013

Replacing the Factor VIII C1 Domain with a Second C2 Domain Reduces Factor VIII Stability and Affinity for Factor IXa

ανά Wakabayashi, Hironao, Fay, Philip J.
Έκδοση 2013

Molecular Orientation of Factor VIIIa on the Phospholipid Membrane Surface Determined by Fluorescence Resonance Energy Transfer

ανά Wakabayashi, Hironao, Fay, Philip J.
Τόπος έκδοσης Biochem J (2013)

Acidic Residues C-Terminal to the A2 Domain Facilitate Thrombin-Catalyzed Activation of Factor VIII

ανά Newell, Jennifer L., Fay, Philip J.
Έκδοση 2008

Cleavage at Arg-1689 Influences Heavy Chain Cleavages during Thrombin-catalyzed Activation of Factor VIII

ανά Newell, Jennifer L., Fay, Philip J.
Έκδοση 2009

Factor VIII Light Chain Contains a Binding Site for Factor X That Contributes to the Catalytic Efficiency of Factor Xase()

ανά Takeyama, Masahiro, Wakabayashi, Hironao, Fay, Philip J.
Έκδοση 2012

Contribution of Factor VIII Light Chain Residues 2007–2016 to an Activated Protein C-Interactive Site

ανά Takeyama, Masahiro, Wakabayashi, Hironao, Fay, Philip J.
Έκδοση 2012

Cofactor Activity in Factor VIIIa of the Blood Clotting Pathway Is Stabilized by an Interdomain Bond between His(281) and Ser(524) Formed in Factor VIII

ανά Wakabayashi, Hironao, Monaghan, Morgan, Fay, Philip J.
Έκδοση 2014

Factor VIII Lacking the C2 Domain Retains Cofactor Activity in Vitro

ανά Wakabayashi, Hironao, Griffiths, Amy E., Fay, Philip J.
Έκδοση 2010

Combining mutations of charged residues at the A2 domain interface enhances factor VIII stability over single point mutations

ανά Wakabayashi, Hironao, Griffiths, Amy E., Fay, Philip J.
Έκδοση 2008

Increasing Hydrophobicity or Disulfide Bridging at the Factor VIII A1 and C2 Domain Interface Enhances Procofactor Stability

ανά Wakabayashi, Hironao, Griffiths, Amy E., Fay, Philip J.
Έκδοση 2011

Factor VIIIa A2 Subunit Shows a High Affinity Interaction with Factor IXa: CONTRIBUTION OF A2 SUBUNIT RESIDUES 707-714 TO THE INTERACTION WITH FACTOR IXa

ανά Griffiths, Amy E., Rydkin, Ivan, Fay, Philip J.
Έκδοση 2013

Combining mutations that modulate inter-subunit interactions and proteolytic inactivation enhance the stability of factor VIIIa()

ανά Wakabayashi, Hironao, Wintermute, Jennifer M., Fay, Philip J.
Τόπος έκδοσης Thromb Haemost (2014)

Thrombin-catalyzed activation of factor VIII with His substituted for Arg372 at the P(1) site

ανά Nogami, Keiji, Zhou, Qian, Wakabayashi, Hironao, Fay, Philip J.
Έκδοση 2005

Sequences Flanking Arg(336) in Factor VIIIa Modulate Factor Xa-catalyzed Cleavage Rates at this Site and Cofactor Function

ανά DeAngelis, Jennifer P., Wakabayashi, Hironao, Fay, Philip J.
Έκδοση 2012

Generation of enhanced stability factor VIII variants by replacement of charged residues at the A2 domain interface

ανά Wakabayashi, Hironao, Varfaj, Fatbardha, DeAngelis, Jennifer, Fay, Philip J.
Έκδοση 2008

Identification of Residues in the 558-Loop of Factor VIIIa A2 Subunit That Interact with Factor IXa

ανά Jagannathan, Indu, Ichikawa, H. Travis, Kruger, Tricia, Fay, Philip J.
Έκδοση 2009

P3-P3' Residues Flanking Scissile Bonds in Factor VIII Modulate Rates of Substrate Cleavage and Procofactor Activation by Thrombin

ανά Newell-Caito, Jennifer L., Griffiths, Amy E., Fay, Philip J.
Έκδοση 2012

Template Dimerization Promotes an Acceptor Invasion-Induced Transfer Mechanism during Human Immunodeficiency Virus Type 1 Minus-Strand Synthesis

ανά Balakrishnan, Mini, Roques, Bernard P., Fay, Philip J., Bambara, Robert A.
Έκδοση 2003