Turoctocog alfa (NovoEight®) – from design to clinical proof of concept

Por Ezban, Mirella, Vad, Knud, Kjalke, Marianne
Publicado no Eur J Haematol (2014)

Proteolytic cleavage of recombinant two-chain factor VIII during cell culture production is mediated by protease(s) from lysed cells. The use of pulse labelling directly in product...

Por Hansen, Karen, Kjalke, Marianne, Rasmussen, Poul Baad, Kongerslev, Leif, Ezban, Mirella
Publicado em 1997

Recombinant human Factor VIIa (rFVIIa) cleared principally by antithrombin following IV administration in Haemophilia Patients

Por Agersø, Henrik, Brophy, Donald F., Pelzer, Hermann, Martin, Erika J., Carr, Marcus, Hedner, Ulla, Ezban, Mirella
Publicado em 2011

Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin

Por Petersen, Lars C., Karpf, Ditte M., Agersø, Henrik, Hermit, Mette B., Pelzer, Hermann, Persson, Egon, Nichols, Timothy C., Ezban, Mirella
Publicado em 2010

Recombinant Factor VIIa Analog NN1731 (V158D/E296V/M298Q-FVIIa) Enhances Fibrin Formation, Structure and Stability in Lipidated Hemophilic Plasma

Por Gray, Laura D., Hussey, Michael A., Larson, Brittany M., Machlus, Kellie R., Campbell, Robert A., Koch, Gary, Ezban, Mirella, Hedner, Ulla, Wolberg, Alisa S.
Publicado em 2011

Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis

Por Sun, Junjiang, Hua, Baolai, Livingston, Eric W., Taves, Sarah, Johansen, Peter B., Hoffman, Maureane, Ezban, Mirella, Monroe, Dougald M., Bateman, Ted A., Monahan, Paul E.
Publicado no Blood (2017)

Successful treatment of canine hemophilia by continuous expression of canine FVIIa

Por Margaritis, Paris, Roy, Elise, Aljamali, Majed N., Downey, Harre D., Giger, Urs, Zhou, Shangzhen, Merricks, Elizabeth, Dillow, Aaron, Ezban, Mirella, Nichols, Timothy C., High, Katherine A.
Publicado em 2009

Prolonged half-life and preserved enzymatic properties of factor IX selectively PEGylated on native N-glycans in the activation peptide

Por Østergaard, Henrik, Bjelke, Jais R., Hansen, Lene, Petersen, Lars Christian, Pedersen, Anette A., Elm, Torben, Møller, Flemming, Hermit, Mette B., Holm, Pernille K., Krogh, Thomas N., Petersen, Jørn M., Ezban, Mirella, Sørensen, Brit B., Andersen, Mette D., Agersø, Henrik, Ahmadian, Haleh, Balling, Kristoffer W., Christiansen, Marie Louise S., Knobe, Karin, Nichols, Timothy C., Bjørn, Søren E., Tranholm, Mikael
Publicado em 2011

A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models

Por Stennicke, Henning R., Kjalke, Marianne, Karpf, Ditte M., Balling, Kristoffer W., Johansen, Peter B., Elm, Torben, Øvlisen, Kristine, Möller, Flemming, Holmberg, Heidi L., Gudme, Charlotte N., Persson, Egon, Hilden, Ida, Pelzer, Hermann, Rahbek-Nielsen, Henrik, Jespersgaard, Christina, Bogsnes, Are, Pedersen, Anette A., Kristensen, Anne K., Peschke, Bernd, Kappers, Wendy, Rode, Frederik, Thim, Lars, Tranholm, Mikael, Ezban, Mirella, Olsen, Eva H. N., Bjørn, Søren E.
Publicado em 2013