A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models

Frequent infusions of intravenous factor VIII (FVIII) are required to prevent bleeding associated with hemophilia A. To reduce the treatment burden, recombinant FVIII with a longer half-life was developed without changing the protein structure. FVIII–polyethylene glycol (PEG) conjugates were prepare...

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Bibliographic Details
Main Authors: Stennicke, Henning R., Kjalke, Marianne, Karpf, Ditte M., Balling, Kristoffer W., Johansen, Peter B., Elm, Torben, Øvlisen, Kristine, Möller, Flemming, Holmberg, Heidi L., Gudme, Charlotte N., Persson, Egon, Hilden, Ida, Pelzer, Hermann, Rahbek-Nielsen, Henrik, Jespersgaard, Christina, Bogsnes, Are, Pedersen, Anette A., Kristensen, Anne K., Peschke, Bernd, Kappers, Wendy, Rode, Frederik, Thim, Lars, Tranholm, Mikael, Ezban, Mirella, Olsen, Eva H. N., Bjørn, Søren E.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2013
Subjects:
Thrombosis and Hemostasis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596971/
https://ncbi.nlm.nih.gov/pubmed/23335368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-407494
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