Recombinant Factor VIIa Analog NN1731 (V158D/E296V/M298Q-FVIIa) Enhances Fibrin Formation, Structure and Stability in Lipidated Hemophilic Plasma

INTRODUCTION: The bypassing agent recombinant factor VIIa (rFVIIa) is efficacious in treating bleeding in hemophilia patients with inhibitors. Efforts have focused on the rational engineering of rFVIIa variants with increased hemostatic potential. One rFVIIa analog (V158D/E296V/M298Q-FVIIa, NN1731)...

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Main Authors: Gray, Laura D., Hussey, Michael A., Larson, Brittany M., Machlus, Kellie R., Campbell, Robert A., Koch, Gary, Ezban, Mirella, Hedner, Ulla, Wolberg, Alisa S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156970/
https://ncbi.nlm.nih.gov/pubmed/21561645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.thromres.2011.04.009
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