Q&A: What are exosomes, exactly?

Por Edgar, James R.
Publicado no BMC Biol (2016)

Hrs- and CD63-Dependent Competing Mechanisms Make Different Sized Endosomal Intraluminal Vesicles

Por Edgar, James R, Eden, Emily R, Futter, Clare E
Publicado no Traffic (2014)

ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation

Por Edgar, James R., Willén, Katarina, Gouras, Gunnar K., Futter, Clare E.
Publicado no J Cell Sci (2015)

Tetherin is an exosomal tether

Por Edgar, James R, Manna, Paul T, Nishimura, Shinichi, Banting, George, Robinson, Margaret S
Publicado no eLife (2016)

The WDR11 complex facilitates the tethering of AP-1-derived vesicles

Por Navarro Negredo, Paloma, Edgar, James R., Manna, Paul T., Antrobus, Robin, Robinson, Margaret S.
Publicado no Nat Commun (2018)

Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A

Por Willén, Katarina, Edgar, James R., Hasegawa, Takafumi, Tanaka, Nobuyuki, Futter, Clare E., Gouras, Gunnar K.
Publicado no Mol Neurodegener (2017)

Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse

Por Lee, Jeansun, Dieckmann, Nele M.G., Edgar, James R., Griffiths, Gillian M., Siegel, Richard M.
Publicado no Immun Inflamm Dis (2018)

Fractionation profiling: a fast and versatile approach for mapping vesicle proteomes and protein–protein interactions

Por Borner, Georg H. H., Hein, Marco Y., Hirst, Jennifer, Edgar, James R., Mann, Matthias, Robinson, Margaret S.
Publicado em 2014

Molecular Mechanisms of Disease Pathogenesis Differ in Krabbe Disease Variants

Por Spratley, Samantha J., Hill, Chris H., Viuff, Agnete H., Edgar, James R., Skjødt, Karsten, Deane, Janet E.
Publicado no Traffic (2016)

Contributions of epsinR and gadkin to clathrin-mediated intracellular trafficking

Por Hirst, Jennifer, Edgar, James R., Borner, Georg H. H., Li, Sam, Sahlender, Daniela A., Antrobus, Robin, Robinson, Margaret S.
Publicado no Mol Biol Cell (2015)

Contribution of the clathrin adaptor AP-1 subunit µ1 to acidic cluster protein sorting

Por Navarro Negredo, Paloma, Edgar, James R., Wrobel, Antoni G., Zaccai, Nathan R., Antrobus, Robin, Owen, David J., Robinson, Margaret S.
Publicado no J Cell Biol (2017)

Role of clathrin in dense core vesicle biogenesis

Por Sahu, Bhavani S., Manna, Paul T., Edgar, James R., Antrobus, Robin, Mahata, Sushil K., Bartolomucci, Alessandro, Borner, Georg H. H., Robinson, Margaret S.
Publicado no Mol Biol Cell (2017)

Defects in ER–endosome contacts impact lysosome function in hereditary spastic paraplegia

Por Allison, Rachel, Edgar, James R., Pearson, Guy, Rizo, Tania, Newton, Timothy, Günther, Sven, Berner, Fiamma, Hague, Jennifer, Connell, James W., Winkler, Jürgen, Lippincott-Schwartz, Jennifer, Beetz, Christian, Winner, Beate, Reid, Evan
Publicado no J Cell Biol (2017)

Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology

Por Clayton, Emma L., Mizielinska, Sarah, Edgar, James R., Nielsen, Troels Tolstrup, Marshall, Sarah, Norona, Frances E., Robbins, Miranda, Damirji, Hana, Holm, Ida E., Johannsen, Peter, Nielsen, Jørgen E., Asante, Emmanuel A., Collinge, John, Isaacs, Adrian M.
Publicado no Acta Neuropathol (2015)

Loss of AP-5 results in accumulation of aberrant endolysosomes: defining a new type of lysosomal storage disease

Por Hirst, Jennifer, Edgar, James R., Esteves, Typhaine, Darios, Frédéric, Madeo, Marianna, Chang, Jaerak, Roda, Ricardo H., Dürr, Alexandra, Anheim, Mathieu, Gellera, Cinzia, Li, Jun, Züchner, Stephan, Mariotti, Caterina, Stevanin, Giovanni, Blackstone, Craig, Kruer, Michael C., Robinson, Margaret S.
Publicado no Hum Mol Genet (2015)

Complicated spastic paraplegia in patients with AP5Z1 mutations (SPG48)

Por Hirst, Jennifer, Madeo, Marianna, Smets, Katrien, Edgar, James R., Schols, Ludger, Li, Jun, Yarrow, Anna, Deconinck, Tine, Baets, Jonathan, Van Aken, Elisabeth, De Bleecker, Jan, Datiles, Manuel B., Roda, Ricardo H., Liepert, Joachim, Züchner, Stephan, Mariotti, Caterina, De Jonghe, Peter, Blackstone, Craig, Kruer, Michael C.
Publicado no Neurol Genet (2016)

Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia

Por Newton, Timothy, Allison, Rachel, Edgar, James R, Lumb, Jennifer H, Rodger, Catherine E, Manna, Paul T, Rizo, Tania, Kohl, Zacharias, Nygren, Anders O H, Arning, Larissa, Schüle, Rebecca, Depienne, Christel, Goldberg, Lisa, Frahm, Christiane, Stevanin, Giovanni, Durr, Alexandra, Schöls, Ludger, Winner, Beate, Beetz, Christian, Reid, Evan
Publicado no Brain (2018)