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Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A
BACKGROUND: Alzheimer’s disease (AD)-linked β-amyloid (Aβ) accumulates in multivesicular bodies (MVBs) with the onset of AD pathogenesis. Alterations in endosomes are among the earliest changes associated with AD but the mechanism(s) that cause endosome enlargement and the effects of MVB dysfunction...
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| Publicado no: | Mol Neurodegener |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5569475/ https://ncbi.nlm.nih.gov/pubmed/28835279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0203-y |
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