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Critical role of intraneuronal Aβ in Alzheimer’s disease: technical challenges in studying intracellular Aβ

AIMS: Multiple lines of evidence have implicated β-amyloid (Aβ) in the pathogenesis of Alzheimer’s disease (AD). However, the mechanism(s) whereby Aβ is involved in the disease process remains unclear. The dominant hypothesis in AD has been that Aβ initiates the disease via toxicity from secreted, e...

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Autors principals: Gouras, Gunnar K., Willén, Katarina, Tampellini, Davide
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479332/
https://ncbi.nlm.nih.gov/pubmed/22727791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2012.06.004
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