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Critical role of intraneuronal Aβ in Alzheimer’s disease: technical challenges in studying intracellular Aβ

AIMS: Multiple lines of evidence have implicated β-amyloid (Aβ) in the pathogenesis of Alzheimer’s disease (AD). However, the mechanism(s) whereby Aβ is involved in the disease process remains unclear. The dominant hypothesis in AD has been that Aβ initiates the disease via toxicity from secreted, e...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Gouras, Gunnar K., Willén, Katarina, Tampellini, Davide
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479332/
https://ncbi.nlm.nih.gov/pubmed/22727791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2012.06.004
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