Impaired β-Amyloid Secretion in Alzheimer's Disease Pathogenesis

A central question in Alzheimer's disease (AD) research is what role β-amyloid peptide (Aβ) plays in synaptic dysfunction. Synaptic activity increases Aβ secretion, potentially inhibiting synapses, but also decreases intraneuronal Aβ, protecting synapses. We now show that levels of secreted Aβ...

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Bibliographic Details
Main Authors: Tampellini, Davide, Rahman, Nawreen, Lin, Michael T., Capetillo-Zarate, Estibaliz, Gouras, Gunnar K.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2011
Subjects:
Brief Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225957/
https://ncbi.nlm.nih.gov/pubmed/22031884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2986-11.2011
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