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ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation

Intracellular amyloid-β (Aβ) accumulation is a key feature of early Alzheimer's disease and precedes the appearance of Aβ in extracellular plaques. Aβ is generated through proteolytic processing of amyloid precursor protein (APP), but the intracellular site of Aβ production is unclear. APP has...

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Bibliografiske detaljer
Udgivet i:J Cell Sci
Main Authors: Edgar, James R., Willén, Katarina, Gouras, Gunnar K., Futter, Clare E.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510853/
https://ncbi.nlm.nih.gov/pubmed/26002056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.170233
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