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Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology
Mutations in the charged multivesicular body protein 2B (CHMP2B) cause frontotemporal dementia (FTD). We report that mice which express FTD-causative mutant CHMP2B at physiological levels develop a novel lysosomal storage pathology characterised by large neuronal autofluorescent aggregates. The aggr...
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Publicado no: | Acta Neuropathol |
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Main Authors: | , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Springer Berlin Heidelberg
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4575387/ https://ncbi.nlm.nih.gov/pubmed/26358247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1475-3 |
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