Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology

Mutations in the charged multivesicular body protein 2B (CHMP2B) cause frontotemporal dementia (FTD). We report that mice which express FTD-causative mutant CHMP2B at physiological levels develop a novel lysosomal storage pathology characterised by large neuronal autofluorescent aggregates. The aggr...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol
Main Authors: Clayton, Emma L., Mizielinska, Sarah, Edgar, James R., Nielsen, Troels Tolstrup, Marshall, Sarah, Norona, Frances E., Robbins, Miranda, Damirji, Hana, Holm, Ida E., Johannsen, Peter, Nielsen, Jørgen E., Asante, Emmanuel A., Collinge, John, Isaacs, Adrian M.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2015
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575387/
https://ncbi.nlm.nih.gov/pubmed/26358247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1475-3
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