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C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci
An expanded GGGGCC repeat in a non-coding region of the C9orf72 gene is a common cause of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis. Non-coding repeat expansions may cause disease by reducing the expression level of the gene they reside in, by producing toxic aggrega...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3830745/ https://ncbi.nlm.nih.gov/pubmed/24170096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-013-1200-z |
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