C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci

An expanded GGGGCC repeat in a non-coding region of the C9orf72 gene is a common cause of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis. Non-coding repeat expansions may cause disease by reducing the expression level of the gene they reside in, by producing toxic aggrega...

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Autores principales: Mizielinska, Sarah, Lashley, Tammaryn, Norona, Frances E., Clayton, Emma L., Ridler, Charlotte E., Fratta, Pietro, Isaacs, Adrian M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2013
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Original Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3830745/
https://ncbi.nlm.nih.gov/pubmed/24170096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-013-1200-z
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