C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia: gain or loss of function?

PURPOSE OF REVIEW: The molecular mechanisms that underlie chromosome 9 open reading frame 72 (C9orf72)-associated amyotrophic lateral sclerosis and frontotemporal dementia are rapidly emerging. Two potential disease mechanisms have been postulated – gain or loss of function. We provide an overview o...

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Autori principali: Mizielinska, Sarah, Isaacs, Adrian M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2014
Soggetti:
NERVE, NEURO-MUSCULAR JUNCTION AND MOTOR NEURON DISEASES: Edited by Kevin Talbot and Angela Vincent
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165481/
https://ncbi.nlm.nih.gov/pubmed/25188012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WCO.0000000000000130
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