C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes

Large expansions of a non-coding GGGGCC-repeat in the first intron of the C9orf72 gene are a common cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). G-rich sequences have a propensity for forming highly stable quadruplex structures in both RNA and DNA termed G-qua...

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Bibliographic Details
Main Authors: Fratta, Pietro, Mizielinska, Sarah, Nicoll, Andrew J., Zloh, Mire, Fisher, Elizabeth M. C., Parkinson, Gary, Isaacs, Adrian M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527825/
https://ncbi.nlm.nih.gov/pubmed/23264878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01016
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