Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration

An intronic GGGGCC expansion in C9orf72 is the most common known cause of both frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The repeat expansion leads to the generation of sense and antisense repeat RNA aggregates and dipeptide repeat (DPR) proteins, generated by...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Mizielinska, Sarah, Ridler, Charlotte E., Balendra, Rubika, Thoeng, Annora, Woodling, Nathan S., Grässer, Friedrich A., Plagnol, Vincent, Lashley, Tammaryn, Partridge, Linda, Isaacs, Adrian M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395972/
https://ncbi.nlm.nih.gov/pubmed/28420437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0432-x
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