Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown

Mutations in the endosome-associated protein CHMP2B cause frontotemporal dementia and lead to lysosomal storage pathology in neurons. We here report that physiological levels of mutant CHMP2B causes reduced numbers and significantly impaired trafficking of endolysosomes within neuronal dendrites, ac...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Brain
Main Authors: Clayton, Emma L, Milioto, Carmelo, Muralidharan, Bhavana, Norona, Frances E, Edgar, James R, Soriano, Armand, Jafar-nejad, Paymaan, Rigo, Frank, Collinge, John, Isaacs, Adrian M
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6262218/
https://ncbi.nlm.nih.gov/pubmed/30496365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awy284
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados