Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown

Mutations in the endosome-associated protein CHMP2B cause frontotemporal dementia and lead to lysosomal storage pathology in neurons. We here report that physiological levels of mutant CHMP2B causes reduced numbers and significantly impaired trafficking of endolysosomes within neuronal dendrites, ac...

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Vydáno v:Brain
Hlavní autoři: Clayton, Emma L, Milioto, Carmelo, Muralidharan, Bhavana, Norona, Frances E, Edgar, James R, Soriano, Armand, Jafar-nejad, Paymaan, Rigo, Frank, Collinge, John, Isaacs, Adrian M
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6262218/
https://ncbi.nlm.nih.gov/pubmed/30496365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awy284
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