TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia

Frontotemporal lobar degeneration (FTLD) is the second leading cause of dementia in individuals under age 65. In many patients, the predominant pathology includes neuronal cytoplasmic or intranuclear inclusions of ubiquitinated TAR DNA binding protein 43 (FTLDTDP). Recently, a genome-wide associatio...

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Auteurs principaux: Nicholson, Alexandra M., Finch, NiCole A., Wojtas, Aleksandra, Baker, Matt C., Perkerson, Ralph B., Castanedes-Casey, Monica, Rousseau, Linda, Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta, Hsiung, Ging-Yuek R., Mackenzie, Ian R., Finger, Elizabeth, Boeve, Bradley F., Ertekin-Taner, Nilüfer, Graff-Radford, Neill R., Dickson, Dennis W., Rademakers, Rosa
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766501/
https://ncbi.nlm.nih.gov/pubmed/23742080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12329
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