Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies

Genetic variants that define two distinct haplotypes at the TMEM106B locus have been implicated in multiple neurodegenerative diseases and in healthy brain ageing. In frontotemporal dementia (FTD), the high expressing TMEM106B risk haplotype was shown to increase susceptibility for FTD with TDP-43 i...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Brain
Päätekijät: Zhou, Xiaolai, Nicholson, Alexandra M, Ren, Yingxue, Brooks, Mieu, Jiang, Peizhou, Zuberi, Aamir, Phuoc, Hung Nguyen, Perkerson, Ralph B, Matchett, Billie, Parsons, Tammee M, Finch, NiCole A, Lin, Wenlang, Qiao, Wenhui, Castanedes-Casey, Monica, Phillips, Virginia, Librero, Ariston L, Asmann, Yan, Bu, Guojun, Murray, Melissa E, Lutz, Cathleen, Dickson, Dennis W, Rademakers, Rosa
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2020
Aiheet:
Original Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296855/
https://ncbi.nlm.nih.gov/pubmed/32504082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awaa141
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