Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies

Genetic variants that define two distinct haplotypes at the TMEM106B locus have been implicated in multiple neurodegenerative diseases and in healthy brain ageing. In frontotemporal dementia (FTD), the high expressing TMEM106B risk haplotype was shown to increase susceptibility for FTD with TDP-43 i...

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Bibliografski detalji
Izdano u:Brain
Glavni autori: Zhou, Xiaolai, Nicholson, Alexandra M, Ren, Yingxue, Brooks, Mieu, Jiang, Peizhou, Zuberi, Aamir, Phuoc, Hung Nguyen, Perkerson, Ralph B, Matchett, Billie, Parsons, Tammee M, Finch, NiCole A, Lin, Wenlang, Qiao, Wenhui, Castanedes-Casey, Monica, Phillips, Virginia, Librero, Ariston L, Asmann, Yan, Bu, Guojun, Murray, Melissa E, Lutz, Cathleen, Dickson, Dennis W, Rademakers, Rosa
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296855/
https://ncbi.nlm.nih.gov/pubmed/32504082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awaa141
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