Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin‐deficient mice

Progranulin (PGRN) and transmembrane protein 106B (TMEM106B) are important lysosomal proteins implicated in frontotemporal lobar degeneration (FTLD) and other neurodegenerative disorders. Loss‐of‐function mutations in progranulin (GRN) are a common cause of FTLD, while TMEM106B variants have been sh...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Zhou, Xiaolai, Brooks, Mieu, Jiang, Peizhou, Koga, Shunsuke, Zuberi, Aamir R, Baker, Matthew C, Parsons, Tammee M, Castanedes‐Casey, Monica, Phillips, Virginia, Librero, Ariston L, Kurti, Aishe, Fryer, John D, Bu, Guojun, Lutz, Cathleen, Dickson, Dennis W, Rademakers, Rosa
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534638/
https://ncbi.nlm.nih.gov/pubmed/32761777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050197
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