Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin‐deficient mice

Progranulin (PGRN) and transmembrane protein 106B (TMEM106B) are important lysosomal proteins implicated in frontotemporal lobar degeneration (FTLD) and other neurodegenerative disorders. Loss‐of‐function mutations in progranulin (GRN) are a common cause of FTLD, while TMEM106B variants have been sh...

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Vydáno v:EMBO Rep
Hlavní autoři: Zhou, Xiaolai, Brooks, Mieu, Jiang, Peizhou, Koga, Shunsuke, Zuberi, Aamir R, Baker, Matthew C, Parsons, Tammee M, Castanedes‐Casey, Monica, Phillips, Virginia, Librero, Ariston L, Kurti, Aishe, Fryer, John D, Bu, Guojun, Lutz, Cathleen, Dickson, Dennis W, Rademakers, Rosa
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534638/
https://ncbi.nlm.nih.gov/pubmed/32761777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050197
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