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Loss of TMEM106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice

Single nucleotide polymorphisms (SNPs) in TMEM106B encoding the lysosomal type II transmembrane protein 106B increase the risk for frontotemporal lobar degeneration (FTLD) of GRN (progranulin gene) mutation carriers. Currently, it is unclear if progranulin (PGRN) and TMEM106B are synergistically lin...

詳細記述

保存先:
書誌詳細
出版年:EMBO Rep
主要な著者: Werner, Georg, Damme, Markus, Schludi, Martin, Gnörich, Johannes, Wind, Karin, Fellerer, Katrin, Wefers, Benedikt, Wurst, Wolfgang, Edbauer, Dieter, Brendel, Matthias, Haass, Christian, Capell, Anja
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534633/
https://ncbi.nlm.nih.gov/pubmed/32929860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050241
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