Loss of TMEM106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice

Single nucleotide polymorphisms (SNPs) in TMEM106B encoding the lysosomal type II transmembrane protein 106B increase the risk for frontotemporal lobar degeneration (FTLD) of GRN (progranulin gene) mutation carriers. Currently, it is unclear if progranulin (PGRN) and TMEM106B are synergistically lin...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:EMBO Rep
Auteurs principaux: Werner, Georg, Damme, Markus, Schludi, Martin, Gnörich, Johannes, Wind, Karin, Fellerer, Katrin, Wefers, Benedikt, Wurst, Wolfgang, Edbauer, Dieter, Brendel, Matthias, Haass, Christian, Capell, Anja
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534633/
https://ncbi.nlm.nih.gov/pubmed/32929860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050241
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires