The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes

TMEM106B is a major risk factor for frontotemporal lobar degeneration with TDP-43 pathology. TMEM106B localizes to lysosomes, but its function remains unclear. We show that TMEM106B knockdown in primary neurons affects lysosomal trafficking and blunts dendritic arborization. We identify microtubule-...

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Autori principali: Schwenk, Benjamin M, Lang, Christina M, Hogl, Sebastian, Tahirovic, Sabina, Orozco, Denise, Rentzsch, Kristin, Lichtenthaler, Stefan F, Hoogenraad, Casper C, Capell, Anja, Haass, Christian, Edbauer, Dieter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2014
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989627/
https://ncbi.nlm.nih.gov/pubmed/24357581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201385857
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