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Loss of fused in sarcoma (FUS) promotes pathological Tau splicing

A subset of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) patients present pathological redistribution and aggregation of the nuclear protein fused in sarcoma (FUS) in the cytoplasm. Although FUS associates with the spliceosomal complex, no endogenous neuronal spli...

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Bibliografiske detaljer
Main Authors: Orozco, Denise, Tahirovic, Sabina, Rentzsch, Kristin, Schwenk, Benjamin M, Haass, Christian, Edbauer, Dieter
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410390/
https://ncbi.nlm.nih.gov/pubmed/22710833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.90
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