Loss of fused in sarcoma (FUS) promotes pathological Tau splicing

A subset of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) patients present pathological redistribution and aggregation of the nuclear protein fused in sarcoma (FUS) in the cytoplasm. Although FUS associates with the spliceosomal complex, no endogenous neuronal spli...

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Detalhes bibliográficos
Main Authors: Orozco, Denise, Tahirovic, Sabina, Rentzsch, Kristin, Schwenk, Benjamin M, Haass, Christian, Edbauer, Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410390/
https://ncbi.nlm.nih.gov/pubmed/22710833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.90
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