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Roles of Ataxin-2 in Pathological Cascades Mediated by TAR DNA-binding Protein 43 (TDP-43) and Fused in Sarcoma (FUS)

The RNA-binding proteins TDP-43 and Fused in Sarcoma (FUS) play central roles in neurodegeneration associated with amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Both proteins are components of messenger ribonucleoprotein (mRNP) granules and show cytoplasmic mislocalization in...

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Hlavní autoři: Nihei, Yoshihiro, Ito, Daisuke, Suzuki, Norihiro
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510829/
https://ncbi.nlm.nih.gov/pubmed/23048034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.398099
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